Pub. Date : 2013 Sep 6
PMID : 23942117
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Arsenic-induced cutaneous hyperplastic lesions are associated with the dysregulation of Yap, a Hippo signaling-related protein. | Arsenic | yes-associated protein 1 | Mus musculus |
| 2 | Thus, as expected, unphosphorylated-Yap was translocated to the nucleus in arsenic-treated epidermis. | Arsenic | yes-associated protein 1 | Mus musculus |
| 3 | Consistently, an up-regulation of Yap-dependent target genes Cyr61, Gli2, Ankrd1 and Ctgf was observed in the skin of arsenic-treated mice. | Arsenic | yes-associated protein 1 | Mus musculus |
| 4 | These data provide evidence that arsenic-induced canonical Hippo signaling pathway and Yap-mediated disruption of tight and adherens junctions are independently regulated. | Arsenic | yes-associated protein 1 | Mus musculus |