Title : IL-18 regulates melanoma VLA-4 integrin activation through a Hierarchized sequence of inflammatory factors.

Pub. Date : 2014 Feb

PMID : 23938462

1 Functional Relationships(s)
Compound Name
Protein Name
1 The cascade involved prostaglandin E2 (PGE2) production from melanoma induced by IL-18-dependent tumor necrosis factor-alpha (TNFalpha); next, PGE2-induced IL-1beta via vascular endothelial growth factor (VEGF) secretion, which in turn induced VLA-4 activation via cyclooxygenase 2-dependent H2O2. Dinoprostone interleukin 1 beta Mus musculus