Pub. Date : 2013 Nov
PMID : 23937324
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The regulation of protein kinase C (PKC) isoforms by ceramide is still controversial. | Ceramides | protein kinase C alpha | Homo sapiens |
| 2 | In this work, the yeast Saccharomyces cerevisiae was used as a model to elucidate the effect of ceramide on the activity of mammalian PKC isoforms. | Ceramides | protein kinase C alpha | Homo sapiens |
| 3 | Moreover, using a yeast-based assay previously developed for the screening of PKC inhibitors, it was also shown that, like the known PKC inhibitor NPC 15437, ceramide reduced the PMA-induced growth inhibition, supporting an inhibitory effect of ceramide on PKCdelta. | Ceramides | protein kinase C alpha | Homo sapiens |
| 4 | Moreover, using a yeast-based assay previously developed for the screening of PKC inhibitors, it was also shown that, like the known PKC inhibitor NPC 15437, ceramide reduced the PMA-induced growth inhibition, supporting an inhibitory effect of ceramide on PKCdelta. | Ceramides | protein kinase C alpha | Homo sapiens |
| 5 | Altogether, these results may indicate that ceramide distinctly interfere with the activity of PKCalpha, delta and zeta. | Ceramides | protein kinase C alpha | Homo sapiens |