Title : Regulation of microRNA expression by rifampin in human hepatocytes.

Pub. Date : 2013 Oct

PMID : 23935064






6 Functional Relationships(s)
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1 Rifampin induced the expression of 10 clinically important and 13 additional P450 genes and repressed the expression of 9 other P450 genes (P < 0.05). Rifampin cytochrome P450 family 2 subfamily B member 6 Homo sapiens
2 Rifampin induced the expression of 10 clinically important and 13 additional P450 genes and repressed the expression of 9 other P450 genes (P < 0.05). Rifampin cytochrome P450 family 2 subfamily B member 6 Homo sapiens
3 Several of these changes were highly negatively correlated with the rifampin-induced changes in the expression of their predicted target P450 mRNAs, supporting the possibility of miRNA-induced regulation of P450 mRNA expression. Rifampin cytochrome P450 family 2 subfamily B member 6 Homo sapiens
4 Several of these changes were highly negatively correlated with the rifampin-induced changes in the expression of their predicted target P450 mRNAs, supporting the possibility of miRNA-induced regulation of P450 mRNA expression. Rifampin cytochrome P450 family 2 subfamily B member 6 Homo sapiens
5 In conclusion, rifampin treatment alters miRNA expression patterns in human hepatocytes, and some of the changes were correlated with the rifampin-induced changes in expression of the P450 mRNAs they are predicted to target. Rifampin cytochrome P450 family 2 subfamily B member 6 Homo sapiens
6 In conclusion, rifampin treatment alters miRNA expression patterns in human hepatocytes, and some of the changes were correlated with the rifampin-induced changes in expression of the P450 mRNAs they are predicted to target. Rifampin cytochrome P450 family 2 subfamily B member 6 Homo sapiens