Pub. Date : 2013 Oct
PMID : 23933653
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Discovery of a retigabine derivative that inhibits KCNQ2 potassium channels. | ezogabine | potassium voltage-gated channel subfamily KQT member 2 | Cricetulus griseus |
| 2 | AIM: Retigabine, an activator of KCNQ2-5 channels, is currently used to treat partial-onset seizures. | ezogabine | potassium voltage-gated channel subfamily KQT member 2 | Cricetulus griseus |
| 3 | The aim of this study was to explore the possibility that structure modification of retigabine could lead to novel inhibitors of KCNQ2 channels, which were valuable tools for KCNQ channel studies. | ezogabine | potassium voltage-gated channel subfamily KQT member 2 | Cricetulus griseus |
| 4 | CONCLUSION: The retigabine derivative HN38 is a potent KCNQ2 inhibitor, which differs from XE991 in its influence on the channel kinetics. | ezogabine | potassium voltage-gated channel subfamily KQT member 2 | Cricetulus griseus |