Title : Discovery of a retigabine derivative that inhibits KCNQ2 potassium channels.

Pub. Date : 2013 Oct

PMID : 23933653






4 Functional Relationships(s)
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1 Discovery of a retigabine derivative that inhibits KCNQ2 potassium channels. ezogabine potassium voltage-gated channel subfamily KQT member 2 Cricetulus griseus
2 AIM: Retigabine, an activator of KCNQ2-5 channels, is currently used to treat partial-onset seizures. ezogabine potassium voltage-gated channel subfamily KQT member 2 Cricetulus griseus
3 The aim of this study was to explore the possibility that structure modification of retigabine could lead to novel inhibitors of KCNQ2 channels, which were valuable tools for KCNQ channel studies. ezogabine potassium voltage-gated channel subfamily KQT member 2 Cricetulus griseus
4 CONCLUSION: The retigabine derivative HN38 is a potent KCNQ2 inhibitor, which differs from XE991 in its influence on the channel kinetics. ezogabine potassium voltage-gated channel subfamily KQT member 2 Cricetulus griseus