Pub. Date : 2013 Nov 15
PMID : 23933011
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The immunophilin FKBP52 is composed of three domains, an FK506-binding domain with peptidyl-prolyl isomerase activity, an FKBP-like domain of unknown function and a TPR-clamp domain, which recognizes the C-terminal peptide of Hsp90 with high affinity. | Tacrolimus | FKBP prolyl isomerase 4 | Homo sapiens |
| 2 | The herein reported crystal structures of FKBP52 reveal that the short linker connecting the FK506-binding domain and the FKBP-like domain acts as a flexible hinge. | Tacrolimus | FKBP prolyl isomerase 4 | Homo sapiens |
| 3 | We further present two co-crystal structures of FKBP52 in complex with the prototypic ligand FK506 and a synthetic analog thereof. | Tacrolimus | FKBP prolyl isomerase 4 | Homo sapiens |