Title : Nucleoside metabolism in herpes simplex virus-infected cells following treatment with interferon and acyclovir, a possible mechanism of synergistic antiviral activity.

Pub. Date : 1990 Jun

PMID : 2393279






5 Functional Relationships(s)
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1 The mechanisms responsible for this synergistic activity are not known, but we hypothesize that IFN-alpha-induced alterations of nucleoside metabolism in virus-infected cells may play an important role. Nucleosides interferon alpha 1 Homo sapiens
2 Although IFN-alpha affected the metabolism of natural nucleosides in HSV-1-infected cells, it did not significantly reduce the uptake of the antiviral guanosine analog acyclovir into HSV-1-infected cells or the amount of acyclovir-5"-triphosphate accumulated. Nucleosides interferon alpha 1 Homo sapiens
3 Therefore, in IFN-alpha-treated cells the concentration of a natural nucleoside, thymidine, was reduced, as were the pools of all deoxyribonucleoside-5"-triphosphates. Nucleosides interferon alpha 1 Homo sapiens
4 These data suggest that IFN-alpha-induced alterations in nucleoside metabolism may be one mechanism whereby IFN-alpha and acyclovir express synergistic antiherpes-virus activity. Nucleosides interferon alpha 1 Homo sapiens
5 These data suggest that IFN-alpha-induced alterations in nucleoside metabolism may be one mechanism whereby IFN-alpha and acyclovir express synergistic antiherpes-virus activity. Nucleosides interferon alpha 1 Homo sapiens