Pub. Date : 2014 Mar
PMID : 23925944
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine induces alteration of H3K27 demethylase UTX in kidney cancer cell. | Nicotine | lysine demethylase 6A | Homo sapiens |
| 2 | To examine the expression change of histone H3 on lysine 27 trimethylase (H3K27me3) demethylases ubiquitously transcribed TPR gene on the X chromosome (UTX) in kidney cancer cell line 786-O after nicotine treatment, quantitative real-time-polymerase chain reaction and western blotting analysis were carried out. | Nicotine | lysine demethylase 6A | Homo sapiens |
| 3 | These results showed that nicotine can increase UTX messenger RNA and protein levels and also decrease the content of H3K27me3. | Nicotine | lysine demethylase 6A | Homo sapiens |
| 4 | Future investigation on nicotine induced UTX expression and its epigenetic effect would deepen our understanding on nicotine toxicity and carcinogenicity. | Nicotine | lysine demethylase 6A | Homo sapiens |
| 5 | Future investigation on nicotine induced UTX expression and its epigenetic effect would deepen our understanding on nicotine toxicity and carcinogenicity. | Nicotine | lysine demethylase 6A | Homo sapiens |