Title : Modified acetylenic steroids as potent mechanism-based inhibitors of cytochrome P-450SCC.

Pub. Date : 1990 Jul 4

PMID : 2391956






3 Functional Relationships(s)
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1 When incubated with the enzyme under turnover conditions, steroid I inactivated cytochrome P-450SCC by about 85% in 40 min. Steroids cytochrome P450 family 11 subfamily A member 1 Homo sapiens
2 The kinetic studies demonstrated that steroids with the tetrahydropyranyl substituent are more potent inhibitors of cytochrome P-450SCC as shown by an initial turnover rate of 0.06 min-1, an inactivation rate constant of 0.05 min-1, and a partition ratio of about 1.0 for steroid I. Steroids cytochrome P450 family 11 subfamily A member 1 Homo sapiens
3 The kinetic studies demonstrated that steroids with the tetrahydropyranyl substituent are more potent inhibitors of cytochrome P-450SCC as shown by an initial turnover rate of 0.06 min-1, an inactivation rate constant of 0.05 min-1, and a partition ratio of about 1.0 for steroid I. Steroids cytochrome P450 family 11 subfamily A member 1 Homo sapiens