Pub. Date : 2013 Jul 23
PMID : 23898401
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sterol homeostasis is essential for the function of cellular membranes and requires feedback inhibition of HMGR, a rate-limiting enzyme of the mevalonate pathway. | Mevalonic Acid | high mobility group AT-hook 1 | Homo sapiens |
| 2 | As HMGR acts at the beginning of the pathway, its regulation affects the synthesis of sterols and of other essential mevalonate-derived metabolites, such as ubiquinone or dolichol. | Mevalonic Acid | high mobility group AT-hook 1 | Homo sapiens |
| 3 | Since the other branch of ERAD is required for HMGR regulation, our results reveal a fundamental role for ERAD in sterol homeostasis, with the two branches of this pathway acting together to control sterol biosynthesis at different levels and thereby allowing independent regulation of multiple products of the mevalonate pathway. | Mevalonic Acid | high mobility group AT-hook 1 | Homo sapiens |