Title : Microcystin (-LR) induced testicular cell apoptosis via up-regulating apoptosis-related genes in vivo.

Pub. Date : 2013 Oct

PMID : 23891578






3 Functional Relationships(s)
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1 The purpose of the study was to find out whether the expression and phosphorylation of p53, Bcl-2 protein family proteins, Cyt c, and caspases were involved in the induction of testicular cell apoptosis by MC-LR in mice. cyanoginosin LR B cell leukemia/lymphoma 2 Mus musculus
2 Significant increases in the phosphorylation of both p53 and Bcl-2 were identified after the administration of MC-LR. cyanoginosin LR B cell leukemia/lymphoma 2 Mus musculus
3 In conclusion, p53, Bcl-2, Bax, Caspase 3 and Caspase 8 are involved in the regulation of MC-LR-induced apoptosis of testicular cells. cyanoginosin LR B cell leukemia/lymphoma 2 Mus musculus