Title : The antibody-based targeted delivery of TNF in combination with doxorubicin eradicates sarcomas in mice and confers protective immunity.

Pub. Date : 2013 Sep 3

PMID : 23887603






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1 The antibody-based pharmacodelivery of TNF by the fusion protein "F8-TNF" to oncofetal fibronectin in sarcoma-bearing mice leads to complete and long-lasting tumour eradications when administered in combination with doxorubicin, the first-line drug for the treatment of sarcomas in humans. Doxorubicin tumor necrosis factor Homo sapiens