Title : Nicotine-modulated subunit stoichiometry affects stability and trafficking of α3β4 nicotinic receptor.

Pub. Date : 2013 Jul 24

PMID : 23884938






1 Functional Relationships(s)
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1 Experimental determinations as well as computational studies of subunit stoichiometry showed that nicotine favors assembly of pentamers with (alpha3)2(beta4)3 stoichiometry; these are less prone than (alpha3)3(beta4)2 receptors to proteasomal degradation and, because of the presence in the beta subunit of an endoplasmic reticulum export motif, more efficiently transported to the plasma membrane. Nicotine tubulin beta 3 class III Homo sapiens