Title : β-Glucosidase 2 (GBA2) activity and imino sugar pharmacology.

Pub. Date : 2013 Sep 6

PMID : 23880767






2 Functional Relationships(s)
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1 Compared with the well characterized impact of CBE on the lysosomal glucosylceramide-degrading enzyme (glucocerebrosidase, GBA), CBE inactivated GBA2 less efficiently, due to a lower affinity for this enzyme (higher KI) and a lower rate of enzyme inactivation (k(inact)). Glucosylceramides glucosidase, beta, acid Mus musculus
2 Compared with the well characterized impact of CBE on the lysosomal glucosylceramide-degrading enzyme (glucocerebrosidase, GBA), CBE inactivated GBA2 less efficiently, due to a lower affinity for this enzyme (higher KI) and a lower rate of enzyme inactivation (k(inact)). Glucosylceramides glucosidase, beta, acid Mus musculus