Pub. Date : 2013 Dec
PMID : 23875783
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Role of adiponectin and its receptor in prediction of reproductive outcome of metformin treatment in patients with polycystic ovarian syndrome. | Metformin | adiponectin, C1Q and collagen domain containing | Homo sapiens |
| 2 | AIMS: The aim of this study was to examine the effect of metformin on serum adiponectin and adiponectin receptor-1 (AdipoR1) and evaluate their role in prediction of ovulation in patients with polycystic ovarian syndrome (PCOS). | Metformin | adiponectin, C1Q and collagen domain containing | Homo sapiens |
| 3 | Group 1 showed post-metformin higher adiponectin and AdipoR1 (P = 0.01) and lower HOMA-IR (P = 0.006) and T (P = 0.001) compared to pre-treatment levels. | Metformin | adiponectin, C1Q and collagen domain containing | Homo sapiens |
| 4 | Post-metformin ovulatory patients had higher adiponectin and AdipoR1 and lower HOMA-IR and T compared to anovulatory patients. | Metformin | adiponectin, C1Q and collagen domain containing | Homo sapiens |
| 5 | CONCLUSIONS: Metformin treatment enhances both adiponectin activity and insulin sensitivity, resulting in a less hyperandrogenic state in patients with PCOS. | Metformin | adiponectin, C1Q and collagen domain containing | Homo sapiens |