Pub. Date : 2013 Oct
PMID : 23873119
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A gene-gene interaction between polymorphisms in the OCT2 and MATE1 genes influences the renal clearance of metformin. | Metformin | solute carrier family 47 member 1 | Homo sapiens |
| 2 | OBJECTIVE: The aim of this study was to determine the association between the renal clearance (CL(renal)) of metformin in healthy Caucasian volunteers and the single-nucleotide polymorphism (SNP) c.808G>T (rs316019) in OCT2 as well as the relevance of the gene-gene interactions between this SNP and (a) the promoter SNP g.-66T>C (rs2252281) in MATE1 and (b) the OCT1 reduced-function diplotypes. | Metformin | solute carrier family 47 member 1 | Homo sapiens |