Title : H-Ras transfers from B to T cells via tunneling nanotubes.

Pub. Date : 2013 Jul 18

PMID : 23868059






3 Functional Relationships(s)
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1 Next, we determined by measuring fluorescence recovery after photobleaching that GFP-H-Ras diffuses freely in the membrane of TNTs that form spontaneously between B and T cells during coculturing. tnts HRas proto-oncogene, GTPase Homo sapiens
2 Importantly, by 4D time-lapse imaging, we showed that GFP-H-Ras-enriched PM patches accumulate at the junction between TNTs and the T-cell body and subsequently transfer to the T-cell surface. tnts HRas proto-oncogene, GTPase Homo sapiens
3 In summary, our data indicate that TNTs connecting B and T cells provide a hitherto undescribed route for the transfer of PM patches containing, for example, H-Ras from B to T cells. tnts HRas proto-oncogene, GTPase Homo sapiens