Pub. Date : 2013 Aug 20
PMID : 23867999
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Deleterious BRCA1/2 mutation is an independent risk factor for carboplatin hypersensitivity reactions. | Carboplatin | BRCA1 DNA repair associated | Homo sapiens |
| 2 | BACKGROUND: We tested the hypothesis that BRCA1/2 mutation carriers with ovarian cancer are at higher risk of carboplatin hypersensitivity reactions (HSRs). | Carboplatin | BRCA1 DNA repair associated | Homo sapiens |
| 3 | Most patients who developed carboplatin HSR had a deleterious BRCA1/2 mutation (93%) vs 50% in patients without HSR (P<0.0001). | Carboplatin | BRCA1 DNA repair associated | Homo sapiens |
| 4 | Multivariable analysis accounting for potential confounding variables including age, history of allergies, and cumulative prior carboplatin cycles confirmed deleterious BRCA1/2 mutation as an independent risk factor for carboplatin HSR (odds ratio 13.1 (95% confidence interval 2.6-65.4), P=0.0017). | Carboplatin | BRCA1 DNA repair associated | Homo sapiens |
| 5 | CONCLUSION: Deleterious BRCA1/2 mutation increased susceptibility and shortened time to carboplatin HSR, independently of other reported factors. | Carboplatin | BRCA1 DNA repair associated | Homo sapiens |