Pub. Date : 2013 Aug
PMID : 23859017
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Cytotoxic concentrations of the nitric oxide donor sodium nitroprusside activated several proapoptotic mechanisms, including stimulation of the stress kinase pathways mediated by c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), inhibition of the translation initiation factor eIF2alpha, induction and phosphorylation of the p53 protein, and inhibited Akt-mediated antiapoptotic signaling, independent of Ras function. | Nitric Oxide | tumor protein p53 | Homo sapiens |