Title : Vorinostat, a HDAC inhibitor, showed anti-osteoarthritic activities through inhibition of iNOS and MMP expression, p38 and ERK phosphorylation and blocking NF-κB nuclear translocation.

Pub. Date : 2013 Oct

PMID : 23856614






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In present study, we investigated whether vorinostat can inhibit the catabolic effects of IL-1beta in vitro, especially the inhibition of MMPs and inducible nitric oxide synthase (iNOS) through the attenuation of nuclear factor kappa-B (NF-kappaB) and mitogen activated protein kinase (MAPK) pathways in human chondrocytes. Vorinostat interleukin 1 beta Homo sapiens
2 Effects of vorinostat on IL-1beta-induced gene and protein expression of iNOS, MMP-1, MMP-13 and tissue inhibitors of metalloproteinase-1 (TIMP-1) were verified by quantitative real time-PCR and Western blot analysis. Vorinostat interleukin 1 beta Homo sapiens
3 In addition, the release of NO, MMP-1 and MMP-13 secreted from IL-1beta stimulated chondrocytes was also suppressed by vorinostat. Vorinostat interleukin 1 beta Homo sapiens
4 Interestingly, vorinostat selectively inhibited IL-1beta-induced p38 and ERK1/2 activation without affecting JNK activation. Vorinostat interleukin 1 beta Homo sapiens