Title : Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARĪ² signaling.

Pub. Date : 2013 Oct

PMID : 23851445






1 Functional Relationships(s)
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1 Furthermore, the ability of ATRA to induce senescence is reduced in p14(ARF)-depleted melanocytes, and we provide proof-of-concept that ATRA can induce irreversible growth arrest in melanoma cells with an intact RARbeta-p14(ARF) signaling axis, independent of p16(INK4A) and p53 status. Tretinoin tumor protein p53 Homo sapiens