Pub. Date : 2013 Aug 22
PMID : 23851396
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Although expressed at very low levels in most tissues, folate receptors, especially FRalpha, are expressed at high levels in numerous cancers to meet the folate demand of rapidly dividing cells under low folate conditions. | Folic Acid | rabaptin, RAB GTPase binding effector protein 2 | Homo sapiens |
| 2 | Although expressed at very low levels in most tissues, folate receptors, especially FRalpha, are expressed at high levels in numerous cancers to meet the folate demand of rapidly dividing cells under low folate conditions. | Folic Acid | rabaptin, RAB GTPase binding effector protein 2 | Homo sapiens |
| 3 | The folate dependency of many tumours has been therapeutically and diagnostically exploited by administration of anti-FRalpha antibodies, high-affinity antifolates, folate-based imaging agents and folate-conjugated drugs and toxins. | Folic Acid | rabaptin, RAB GTPase binding effector protein 2 | Homo sapiens |
| 4 | To understand how folate binds its receptors, we determined the crystal structure of human FRalpha in complex with folic acid at 2.8 A resolution. | Folic Acid | rabaptin, RAB GTPase binding effector protein 2 | Homo sapiens |
| 5 | To understand how folate binds its receptors, we determined the crystal structure of human FRalpha in complex with folic acid at 2.8 A resolution. | Folic Acid | rabaptin, RAB GTPase binding effector protein 2 | Homo sapiens |
| 6 | FRalpha has a globular structure stabilized by eight disulphide bonds and contains a deep open folate-binding pocket comprised of residues that are conserved in all receptor subtypes. | Folic Acid | rabaptin, RAB GTPase binding effector protein 2 | Homo sapiens |