Title : Brain-derived neurotrophic factor-mediated downregulation of brainstem K+-Cl- cotransporter and cell-type-specific GABA impairment for activation of descending pain facilitation.

Pub. Date : 2013 Oct

PMID : 23847084






1 Functional Relationships(s)
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1 These findings demonstrate a cellular mechanism by which the hyperactivity of NRM MOR-expressing neurons, presumably responsible for descending pain facilitation, contributes to pain sensitization through the signaling cascade of BDNF-KCC2-GABA impairment in the development of chronic pain. gamma-Aminobutyric Acid solute carrier family 12 member 5 Rattus norvegicus