Title : Caspase blockade induces RIP3-mediated programmed necrosis in Toll-like receptor-activated microglia.

Pub. Date : 2013 Jul 11

PMID : 23846218






1 Functional Relationships(s)
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1 We report here that microglia activated through Toll-like receptors (TLRs) undergo RIP1/RIP3-dependent programmed necrosis (necroptosis) when exposed to the pan caspase inhibitor zVAD-fmk. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone receptor (TNFRSF)-interacting serine-threonine kinase 1 Mus musculus