Title : The omega-3 polyunsaturated fatty acid DHA induces simultaneous apoptosis and autophagy via mitochondrial ROS-mediated Akt-mTOR signaling in prostate cancer cells expressing mutant p53.

Pub. Date : 2013

PMID : 23841076






3 Functional Relationships(s)
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1 The omega-3 polyunsaturated fatty acid DHA induces simultaneous apoptosis and autophagy via mitochondrial ROS-mediated Akt-mTOR signaling in prostate cancer cells expressing mutant p53. Docosahexaenoic Acids AKT serine/threonine kinase 1 Homo sapiens
2 Further, DHA reduced the levels of phospho-Akt and phospho-mTOR in a concentration-dependent manner, while NAC almost completely blocked that effect. Docosahexaenoic Acids AKT serine/threonine kinase 1 Homo sapiens
3 Collectively, these findings present a novel mechanism of ROS-regulated apoptosis and autophagy that involves Akt-mTOR signaling in prostate cancer cells with mutant p53 exposed to DHA. Docosahexaenoic Acids AKT serine/threonine kinase 1 Homo sapiens