Title : Involvement of NF-κB and muscle specific E3 ubiquitin ligase MuRF1 in cigarette smoke-induced catabolism in C2 myotubes.

Pub. Date : 2013

PMID : 23835952






2 Functional Relationships(s)
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1 Also, C2 exposure to CS resulted in IkappaB-alpha degradation and NF-kappaB activation, which led to upregulation of the muscle specific E3 ubiquitin ligase MuRF1, but not MAFbx/atrogin-1. Cesium tripartite motif containing 63 Homo sapiens
2 In conclusion, our results demonstrate that vapor phase CS exposure to skeletal myotubes triggers NF-kappaB activation leading to skeletal muscle cell damage and breakdown of muscle proteins mediated by muscle specific E3 ubiquitin ligase MuRF1. Cesium tripartite motif containing 63 Homo sapiens