Title : Expansion of a PBPK model to predict disposition in pregnant women of drugs cleared via multiple CYP enzymes, including CYP2B6, CYP2C9 and CYP2C19.

Pub. Date : 2014 Mar

PMID : 23834474






1 Functional Relationships(s)
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1 For verification, the pregnancy-related changes in the disposition of methadone (cleared by CYP2B6, 3A and 2C19) and glyburide (cleared by CYP3A, 2C9 and 2C19) were predicted. Methadone cytochrome P450 family 2 subfamily B member 6 Homo sapiens