Pub. Date : 2013 Dec
PMID : 23831190
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we provide substantial biochemical evidence that the heme enzyme Ccp1 (cytochrome c peroxidase), which is targeted to the intermembrane space, functions primarily as a mitochondrial H2O2 sensing and signaling protein in Saccharomyces cerevisiae. | Hydrogen Peroxide | cytochrome-c peroxidase | Saccharomyces cerevisiae S288C |
| 2 | Key evidence for a sensing role for Ccp1 is the significantly higher H2O2 accumulation in ccp1-null cells(ccp1Delta) vs ccp1(W191F) cells producing the catalytically inactive Ccp1(W191F) variant. | Hydrogen Peroxide | cytochrome-c peroxidase | Saccharomyces cerevisiae S288C |
| 3 | Key evidence for a sensing role for Ccp1 is the significantly higher H2O2 accumulation in ccp1-null cells(ccp1Delta) vs ccp1(W191F) cells producing the catalytically inactive Ccp1(W191F) variant. | Hydrogen Peroxide | cytochrome-c peroxidase | Saccharomyces cerevisiae S288C |
| 4 | Key evidence for a sensing role for Ccp1 is the significantly higher H2O2 accumulation in ccp1-null cells(ccp1Delta) vs ccp1(W191F) cells producing the catalytically inactive Ccp1(W191F) variant. | Hydrogen Peroxide | cytochrome-c peroxidase | Saccharomyces cerevisiae S288C |
| 5 | In fact, intracellular H2O2 levels (ccp1Delta>wildtype >ccp1(W191F)) correlate inversely with the activity of the mitochondrial (and peroxisomal) heme catalase, Cta1 (ccp1Delta<wildtype <ccp1(W191F)). | Hydrogen Peroxide | cytochrome-c peroxidase | Saccharomyces cerevisiae S288C |
| 6 | In fact, intracellular H2O2 levels (ccp1Delta>wildtype >ccp1(W191F)) correlate inversely with the activity of the mitochondrial (and peroxisomal) heme catalase, Cta1 (ccp1Delta<wildtype <ccp1(W191F)). | Hydrogen Peroxide | cytochrome-c peroxidase | Saccharomyces cerevisiae S288C |
| 7 | Notably, Ccp1(W191F) is a more persistent H2O2 signaling protein than wild-type Ccp1, and this enhanced mitochondrial H2O2 signaling decreases the mitochondrial fitness of ccp1(W191F) cells. | Hydrogen Peroxide | cytochrome-c peroxidase | Saccharomyces cerevisiae S288C |
| 8 | Notably, Ccp1(W191F) is a more persistent H2O2 signaling protein than wild-type Ccp1, and this enhanced mitochondrial H2O2 signaling decreases the mitochondrial fitness of ccp1(W191F) cells. | Hydrogen Peroxide | cytochrome-c peroxidase | Saccharomyces cerevisiae S288C |
| 9 | Notably, Ccp1(W191F) is a more persistent H2O2 signaling protein than wild-type Ccp1, and this enhanced mitochondrial H2O2 signaling decreases the mitochondrial fitness of ccp1(W191F) cells. | Hydrogen Peroxide | cytochrome-c peroxidase | Saccharomyces cerevisiae S288C |
| 10 | Combined, our results strongly implicate Ccp1, independent of its peroxidase activity, in mitochondrial H2O2 sensing and signaling to maintain reactive oxygen species homeostasis. | Hydrogen Peroxide | cytochrome-c peroxidase | Saccharomyces cerevisiae S288C |