Title : Dephosphorylation of intact glycoprotein to greatly improve digestion efficiency coupled with matrix-assisted laser desorption/ionization-Fourier transform ion cyclotron resonance mass spectrometric analysis.

Pub. Date : 2013 Jul 17

PMID : 23830432






2 Functional Relationships(s)
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1 In addition, the approach was applied to characterize the sialylated status of alpha2-macroglobulin and transferrin, respectively, from the sera of healthy subjects and sex- and age-matched patients with thyroid cancer, and their spectra indicate that the change in the amount of the glycoforms containing different number of sialic acid (SA) residues from one glycosylation site may be used to differentiate between healthy subjects and cancer cases. N-Acetylneuraminic Acid transferrin Homo sapiens
2 In addition, the approach was applied to characterize the sialylated status of alpha2-macroglobulin and transferrin, respectively, from the sera of healthy subjects and sex- and age-matched patients with thyroid cancer, and their spectra indicate that the change in the amount of the glycoforms containing different number of sialic acid (SA) residues from one glycosylation site may be used to differentiate between healthy subjects and cancer cases. N-Acetylneuraminic Acid transferrin Homo sapiens