Pub. Date : 2013 Jun
PMID : 23825968
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, Dnl4 catalytic point mutants were generated that were severely defective in auto-adenylation in vitro and NHEJ activity in vivo, despite being hyper-recruited to DSBs and supporting wild-type levels of Lif1 interaction and assembly of a Ku- and Lif1-containing complex at DSBs. | dsbs | DNA ligase (ATP) DNL4 | Saccharomyces cerevisiae S288C |
| 2 | Here, Dnl4 catalytic point mutants were generated that were severely defective in auto-adenylation in vitro and NHEJ activity in vivo, despite being hyper-recruited to DSBs and supporting wild-type levels of Lif1 interaction and assembly of a Ku- and Lif1-containing complex at DSBs. | dsbs | DNA ligase (ATP) DNL4 | Saccharomyces cerevisiae S288C |
| 3 | Enrichment of DNA ligase I (Cdc9 in yeast) at DSBs was observed in wild-type as well as dnl4 point mutant strains, with both Dnl4 and Cdc9 disappearing from DSBs upon 5" resection that was unimpeded by the presence of catalytically inactive Dnl4. | dsbs | DNA ligase (ATP) DNL4 | Saccharomyces cerevisiae S288C |
| 4 | Enrichment of DNA ligase I (Cdc9 in yeast) at DSBs was observed in wild-type as well as dnl4 point mutant strains, with both Dnl4 and Cdc9 disappearing from DSBs upon 5" resection that was unimpeded by the presence of catalytically inactive Dnl4. | dsbs | DNA ligase (ATP) DNL4 | Saccharomyces cerevisiae S288C |
| 5 | Enrichment of DNA ligase I (Cdc9 in yeast) at DSBs was observed in wild-type as well as dnl4 point mutant strains, with both Dnl4 and Cdc9 disappearing from DSBs upon 5" resection that was unimpeded by the presence of catalytically inactive Dnl4. | dsbs | DNA ligase (ATP) DNL4 | Saccharomyces cerevisiae S288C |
| 6 | Enrichment of DNA ligase I (Cdc9 in yeast) at DSBs was observed in wild-type as well as dnl4 point mutant strains, with both Dnl4 and Cdc9 disappearing from DSBs upon 5" resection that was unimpeded by the presence of catalytically inactive Dnl4. | dsbs | DNA ligase (ATP) DNL4 | Saccharomyces cerevisiae S288C |
| 7 | Enrichment of DNA ligase I (Cdc9 in yeast) at DSBs was observed in wild-type as well as dnl4 point mutant strains, with both Dnl4 and Cdc9 disappearing from DSBs upon 5" resection that was unimpeded by the presence of catalytically inactive Dnl4. | dsbs | DNA ligase (ATP) DNL4 | Saccharomyces cerevisiae S288C |