Title : Negative regulation of TLR inflammatory signaling by the SUMO-deconjugating enzyme SENP6.

Pub. Date : 2013

PMID : 23825957






2 Functional Relationships(s)
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1 Mechanistically, the small ubiquitin-like modifier 2/3 (SUMO-2/3) is conjugated onto the Lysine residue 277 of NF-kappaB essential modifier (NEMO/IKKgamma), and this impairs the deubiquitinase CYLD to bind NEMO, thus strengthening the inhibitor of kappaB kinase (IKK) activation. Lysine small ubiquitin-like modifier 2 Mus musculus
2 Mechanistically, the small ubiquitin-like modifier 2/3 (SUMO-2/3) is conjugated onto the Lysine residue 277 of NF-kappaB essential modifier (NEMO/IKKgamma), and this impairs the deubiquitinase CYLD to bind NEMO, thus strengthening the inhibitor of kappaB kinase (IKK) activation. Lysine small ubiquitin-like modifier 2 Mus musculus