Title : Sulforaphane accelerates acetaldehyde metabolism by inducing aldehyde dehydrogenases: relevance to ethanol intolerance.

Pub. Date : 2013 Sep-Oct

PMID : 23825090






2 Functional Relationships(s)
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1 METHODS: Sulforaphane [SF, 1-isothiocyano-4-(methylsulfinyl)butane] derived from its glucosinolate precursor contained in cruciferous vegetables and related inducers of the Keap1/Nrf2/ARE pathway were assessed for their potencies to induce ALDH in murine hepatoma Hepa1c1c7 cells. sulforaphane aldehyde dehydrogenase family 3, subfamily A1 Mus musculus
2 In mice, in vivo, feeding of SF induced tissue ALDH and dramatically increased (doubled) the rate of elimination of acetaldehyde arising from the administration of ethanol. sulforaphane aldehyde dehydrogenase family 3, subfamily A1 Mus musculus