Title : Ubiquitination and degradation of CFTR by the E3 ubiquitin ligase MARCH2 through its association with adaptor proteins CAL and STX6.

Pub. Date : 2013

PMID : 23818989






1 Functional Relationships(s)
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1 In vivo ubiquitination assays demonstrated the ubiquitination of CFTR by MARCH2, and overexpression of MARCH2, like that of CAL and STX6, led to a dose-dependent degradation of mature CFTR that was blocked by bafilomycin A1 treatment. bafilomycin golgi associated PDZ and coiled-coil motif containing Homo sapiens