Title : The presence of outer arm fucose residues on the N-glycans of tissue inhibitor of metalloproteinases-1 reduces its activity.

Pub. Date : 2013 Aug 2

PMID : 23815085






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Further analyses showed that cleavage of outer arm fucose residues from the N-glycans of 293 TIMP-1 or knockdown of both FUT4 and FUT7 (which encode for fucosyltransferases that add outer arm fucose residues to N-glycans) enhanced the MMP-binding and catalytic abilities of 293 TIMP-1, bringing them up to the levels of the other TIMP-1. n-glycans fucosyltransferase 4 Homo sapiens