Pub. Date : 2013 Aug 9
PMID : 23814050
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Methionine adenosyltransferase 2B, HuR, and sirtuin 1 protein cross-talk impacts on the effect of resveratrol on apoptosis and growth in liver cancer cells. | Resveratrol | methionine adenosyltransferase 2B | Homo sapiens |
| 2 | Interestingly, crystal structure analysis of MAT2B protein (MATbeta) protomer revealed two resveratrol binding pockets, which raises the question of the role of MAT2B in resveratrol biological activities. | Resveratrol | methionine adenosyltransferase 2B | Homo sapiens |
| 3 | Following resveratrol treatment, HuR expression increased first, followed by SIRT1 and MAT2B. | Resveratrol | methionine adenosyltransferase 2B | Homo sapiens |
| 4 | Induction of MAT2B is a compensatory response to resveratrol as knocking down MAT2BV1 potentiated the resveratrol pro-apoptotic and growth-suppressive effects, whereas the opposite occurred with V1 overexpression. | Resveratrol | methionine adenosyltransferase 2B | Homo sapiens |
| 5 | Induction of MAT2B is a compensatory response to resveratrol as knocking down MAT2BV1 potentiated the resveratrol pro-apoptotic and growth-suppressive effects, whereas the opposite occurred with V1 overexpression. | Resveratrol | methionine adenosyltransferase 2B | Homo sapiens |
| 6 | In conclusion, resveratrol induces HuR, SIRT1, and MAT2B expression; the last may represent a compensatory response against apoptosis and growth inhibition. | Resveratrol | methionine adenosyltransferase 2B | Homo sapiens |