Title : Identification of 2-piperidone as a biomarker of CYP2E1 activity through metabolomic phenotyping.

Pub. Date : 2013 Sep

PMID : 23811823






2 Functional Relationships(s)
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1 The accumulation of 2-piperidone in the Cyp2e1-null mice was mainly caused by the changes in the biosynthesis and degradation of 2-piperidone because compared with the WT mice, the conversion of cadaverine to 2-piperidone was higher, whereas the metabolism of 2-piperidone to 6-hydroxy-2-piperidone was lower in the Cyp2e1-null mice. Cadaverine cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus
2 The accumulation of 2-piperidone in the Cyp2e1-null mice was mainly caused by the changes in the biosynthesis and degradation of 2-piperidone because compared with the WT mice, the conversion of cadaverine to 2-piperidone was higher, whereas the metabolism of 2-piperidone to 6-hydroxy-2-piperidone was lower in the Cyp2e1-null mice. Cadaverine cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus