Title : Insulin-like growth factor binding protein-3 (IGFBP-3) plays a role in the anti-tumorigenic effects of 5-Aza-2'-deoxycytidine (AZA) in breast cancer cells.

Pub. Date : 2013 Aug 15

PMID : 23810988






1 Functional Relationships(s)
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1 With ER-alpha positive cells AZA increased the abundance of the tumour suppressor gene, p53 and induced demethylation of the IGFBP-3 promoter, whereas with ER negative cells, AZA epigenetically increased the transcription factor AP2-alpha, which when silenced prevented the increase in IGFBP-3. Decitabine tumor protein p53 Homo sapiens