Pub. Date : 2013 Oct
PMID : 23800789
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The IL17A and IL17F loci have divergent histone modifications and are differentially regulated by prostaglandin E2 in Th17 cells. | Dinoprostone | interleukin 17A | Homo sapiens |
| 2 | Prostaglandin E2 (PGE2), IL-23 and IL-1beta are implicated in inflammatory bowel disease susceptibility, likely in part by modulating IL-17 producing CD4(+) T helper (Th17) cells. | Dinoprostone | interleukin 17A | Homo sapiens |
| 3 | Prostaglandin E2 (PGE2), IL-23 and IL-1beta are implicated in inflammatory bowel disease susceptibility, likely in part by modulating IL-17 producing CD4(+) T helper (Th17) cells. | Dinoprostone | interleukin 17A | Homo sapiens |
| 4 | To better understand how these three mediators affect Th17 cell memory responses, we characterized the gene expression profiles of activated human peripheral CD4(+) effector memory T cells and sorted Th17 memory cells from healthy donors concurrent with IL17A mRNA induction mediated by PGE2 and/or IL-23 plus IL-1beta. | Dinoprostone | interleukin 17A | Homo sapiens |
| 5 | We discovered that PGE2 and IL-23 plus IL-1beta differentially regulate Th17 cytokine expression and synergize to induce IL-17A, but not IL-17F. | Dinoprostone | interleukin 17A | Homo sapiens |
| 6 | The addition of PGE2 to IL-23 plus IL-1beta only enhances IL-17A expression as mediated by the PGE2 EP4 receptor, and promotes a switch from an IL-17F to an IL-17A predominant immune response. | Dinoprostone | interleukin 17A | Homo sapiens |
| 7 | The addition of PGE2 to IL-23 plus IL-1beta only enhances IL-17A expression as mediated by the PGE2 EP4 receptor, and promotes a switch from an IL-17F to an IL-17A predominant immune response. | Dinoprostone | interleukin 17A | Homo sapiens |