Pub. Date : 2013 Oct 1
PMID : 23800229
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The mitochondrial carrier Rim2 co-imports pyrimidine nucleotides and iron. | Pyrimidine Nucleotides | Rim2p | Saccharomyces cerevisiae S288C |
| 2 | In the present study we show by in vitro transport studies that Rim2 mediates the transport of iron and other divalent metal ions across the mitochondrial inner membrane in a pyrimidine nucleotide-dependent fashion. | Pyrimidine Nucleotides | Rim2p | Saccharomyces cerevisiae S288C |
| 3 | Mutations in the proposed substrate-binding site of Rim2 prevent both pyrimidine nucleotide and divalent ion transport. | Pyrimidine Nucleotides | Rim2p | Saccharomyces cerevisiae S288C |
| 4 | These results document that Rim2 catalyses the co-import of pyrimidine nucleotides and divalent metal ions including ferrous iron. | Pyrimidine Nucleotides | Rim2p | Saccharomyces cerevisiae S288C |