Pub. Date : 2013
PMID : 23799016
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Celastrol prevents atherosclerosis via inhibiting LOX-1 and oxidative stress. | celastrol | oxidized low density lipoprotein (lectin-like) receptor 1 | Mus musculus |
| 2 | We found that celastrol significantly attenuated oxLDL-induced excessive expression of lectin-like oxidized low density lipoprotein receptor-1(LOX-1) and generation of reactive oxygen species (ROS) in cultured RAW264.7 macrophages. | celastrol | oxidized low density lipoprotein (lectin-like) receptor 1 | Mus musculus |
| 3 | The expression of LOX-1 within the atherosclerotic lesions and generation of superoxide in mouse aorta were also significantly reduced by celastrol while the lipid profile was not improved. | celastrol | oxidized low density lipoprotein (lectin-like) receptor 1 | Mus musculus |
| 4 | In conclusion, our results show that celastrol inhibits atherosclerotic plaque developing in apoE(-/-) mice via inhibiting LOX-1 and oxidative stress. | celastrol | oxidized low density lipoprotein (lectin-like) receptor 1 | Mus musculus |