Title : Knockdown of N-acetylglucosaminyl transferase V ameliorates hepatotoxin-induced liver fibrosis in mice.

Pub. Date : 2013 Sep

PMID : 23798564






3 Functional Relationships(s)
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1 Here, we induced mouse liver fibrosis by ip injections of carbon tetrachloride (CCl4) or thioacetamide (TAA) and observed significant increase of hepatic GnT-V during the processes of liver fibrogenesis. Carbon Tetrachloride mannoside acetylglucosaminyltransferase 5 Mus musculus
2 Here, we induced mouse liver fibrosis by ip injections of carbon tetrachloride (CCl4) or thioacetamide (TAA) and observed significant increase of hepatic GnT-V during the processes of liver fibrogenesis. Carbon Tetrachloride mannoside acetylglucosaminyltransferase 5 Mus musculus
3 Adenovirus-mediated delivery of GnT-V siRNA dramatically reduced the GnT-V expression in fibrotic liver and activated HSC in vivo and consequently alleviated CCl4- or TAA-induced liver fibrosis as assessed through collagen deposition and profiles of profibrogenic markers. Carbon Tetrachloride mannoside acetylglucosaminyltransferase 5 Mus musculus