Title : Potent inhibition of aldehyde dehydrogenase-2 by diphenyleneiodonium: focus on nitroglycerin bioactivation.

Pub. Date : 2013 Sep

PMID : 23793290






1 Functional Relationships(s)
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1 Denitration and bioactivation of 1-2 microM GTN, assayed as 1,2-glycerol dinitrate formation and activation of purified sGC, respectively, were inhibited by DPI with a half-maximally active concentration of about 0.2 microM in a GTN-competitive manner. diphenyleneiodonium guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus