Pub. Date : 2013 Sep
PMID : 23793290
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Potent inhibition of aldehyde dehydrogenase-2 by diphenyleneiodonium: focus on nitroglycerin bioactivation. | diphenyleneiodonium | aldehyde dehydrogenase 1 family, member A1 | Rattus norvegicus |
| 2 | However, the ALDH2 hypothesis has not been reconciled with early studies demonstrating potent inhibition of the GTN response by diphenyleneiodonium (DPI), a widely used inhibitor of flavoproteins, in particular NADPH oxidases. | diphenyleneiodonium | aldehyde dehydrogenase 1 family, member A1 | Rattus norvegicus |
| 3 | However, the ALDH2 hypothesis has not been reconciled with early studies demonstrating potent inhibition of the GTN response by diphenyleneiodonium (DPI), a widely used inhibitor of flavoproteins, in particular NADPH oxidases. | diphenyleneiodonium | aldehyde dehydrogenase 1 family, member A1 | Rattus norvegicus |
| 4 | Molecular modeling indicated that DPI binds to the catalytic site of ALDH2, and this was confirmed by experiments showing substrate-competitive inhibition of the dehydrogenase and esterase activities of the enzyme. | diphenyleneiodonium | aldehyde dehydrogenase 1 family, member A1 | Rattus norvegicus |
| 5 | Our data identify ALDH2 as highly sensitive target of DPI and explain inhibition of GTN-induced relaxation by this drug observed previously. | diphenyleneiodonium | aldehyde dehydrogenase 1 family, member A1 | Rattus norvegicus |