Pub. Date : 2013 Aug 29
PMID : 23777768
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2alpha mRNA translation. | Iron | aconitase 1 | Mus musculus |
| 2 | The presence of an iron-responsive element (IRE) within the 5" untranslated region of HIF2alpha mRNA suggests a further iron- and oxygen-dependent mechanism for translational regulation of its expression via iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively). | Iron | aconitase 1 | Mus musculus |
| 3 | The presence of an iron-responsive element (IRE) within the 5" untranslated region of HIF2alpha mRNA suggests a further iron- and oxygen-dependent mechanism for translational regulation of its expression via iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively). | Iron | aconitase 1 | Mus musculus |
| 4 | The presence of an iron-responsive element (IRE) within the 5" untranslated region of HIF2alpha mRNA suggests a further iron- and oxygen-dependent mechanism for translational regulation of its expression via iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively). | Iron | aconitase 1 | Mus musculus |
| 5 | We show here that the disruption of mouse IRP1, but not IRP2, leads to profound HIF2alpha-dependent abnormalities in erythropoiesis and systemic iron metabolism. | Iron | aconitase 1 | Mus musculus |