Pub. Date : 2013
PMID : 23776497
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Resistin production from adipose tissue is decreased in db/db obese mice, and is reversed by rosiglitazone. | Rosiglitazone | resistin | Mus musculus |
| 2 | OBJECTIVE: This study was designed to (1) investigate the expression profiles of resistin in db/db mice and its dynamic association with metabolic parameters; and (2) evaluate the effects of Rosiglitazone on production of resistin. | Rosiglitazone | resistin | Mus musculus |
| 3 | Notably, treatment with rosiglitazone increased the serum resistin levels by 66.4%(P<0.05)in db/db mice. | Rosiglitazone | resistin | Mus musculus |
| 4 | In 3T3-L1 adipocytes, Rosiglitazone (10 uM) markedly enhanced the secretion of resistin by 120% (P<0.01) and its gene expression by 78.1% (P<0.05). | Rosiglitazone | resistin | Mus musculus |
| 5 | CONCLUSION: Both resistin gene expression and its secretion from the epididymal adipose tissue were decreased in db/db obese mice, while the insulin-sensitizing drug rosiglitazone increased resistin production. | Rosiglitazone | resistin | Mus musculus |