Title : Zebularine partially reverses GST methylation in prostate cancer cells and restores sensitivity to the DNA minor groove binder brostallicin.

Pub. Date : 2013 Jun

PMID : 23771052






3 Functional Relationships(s)
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1 Zebularine partially reverses GST methylation in prostate cancer cells and restores sensitivity to the DNA minor groove binder brostallicin. pyrimidin-2-one beta-ribofuranoside glutathione S-transferase kappa 1 Homo sapiens
2 These results indicate that zebularine, both in vitro and in vivo, enhances the activity of brostallicin and that this enhancement correlates with re-expression of GST-pi and GST-mu. pyrimidin-2-one beta-ribofuranoside glutathione S-transferase kappa 1 Homo sapiens
3 These results indicate that zebularine, both in vitro and in vivo, enhances the activity of brostallicin and that this enhancement correlates with re-expression of GST-pi and GST-mu. pyrimidin-2-one beta-ribofuranoside glutathione S-transferase kappa 1 Homo sapiens