Pub. Date : 2010
PMID : 23762931
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ML298 displays no inhibition of PLD1, and therefore is an improvement over our first generation PLD2 selective inhibitor, VU0364739 (cellular PLD1, IC50 = 1,500 nM, cellular PLD2, IC50 = 20 nM), as at standard in vitro doses, and in vivo exposure levels, both PLD1 and PLD2 are inhibited. | VU0364739 | phospholipase D1 | Homo sapiens |
| 2 | ML298 displays no inhibition of PLD1, and therefore is an improvement over our first generation PLD2 selective inhibitor, VU0364739 (cellular PLD1, IC50 = 1,500 nM, cellular PLD2, IC50 = 20 nM), as at standard in vitro doses, and in vivo exposure levels, both PLD1 and PLD2 are inhibited. | VU0364739 | phospholipase D1 | Homo sapiens |