Pub. Date : 2013 Sep
PMID : 23759247
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The role of TC-PTP (PTPN2) in modulating sensitivity to imatinib and interferon-alpha in CML cell line, KT-1 cells. | Imatinib Mesylate | protein tyrosine phosphatase, non-receptor type 2 | Mus musculus |
| 2 | The role of TC-PTP (PTPN2) in modulating sensitivity to imatinib and interferon-alpha in CML cell line, KT-1 cells. | Imatinib Mesylate | protein tyrosine phosphatase, non-receptor type 2 | Mus musculus |
| 3 | Suppression of TC-PTP induced activation of STAT5, leading to imatinib resistance, while prolonged phosphorylation of STAT1 was induced by IFN-alpha, triggering cell death in KT-1 cells. | Imatinib Mesylate | protein tyrosine phosphatase, non-receptor type 2 | Mus musculus |
| 4 | These findings suggest that TC-PTP modulates sensitivity to imatinib and IFN-alpha in CML. | Imatinib Mesylate | protein tyrosine phosphatase, non-receptor type 2 | Mus musculus |