Pub. Date : 2013 Oct
PMID : 23758063
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We studied the beta-lactamase activity of HSA on clinically significant antibiotics of cephalosporin group in the presence of environmental pollutants by determining specific activity, enzyme kinetics and minimum inhibitory concentrations (MIC). | Cephalosporins | albumin | Homo sapiens |
| 2 | The specific activity of HSA on various cephalosporins was found to be 1181-34 550 times lower than that observed for recombinant CTX-M-15 (used as positive control). | Cephalosporins | albumin | Homo sapiens |
| 3 | The MIC data also showed that HSA is incapable of hydrolysing cephalosporins. | Cephalosporins | albumin | Homo sapiens |
| 4 | The study concludes that HSA is inefficient to cleave antibiotics of cephalosporin group and hence does not contribute to nonmicrobial-based antibiotic resistance. | Cephalosporins | albumin | Homo sapiens |
| 5 | Our results showed that HSA is inefficient in cleaving nitrocefin as compared to a true beta-lactamase (CTX-M-15) and is practically inactive on cephalosporin antibiotics even in the presence pollutants. | Cephalosporins | albumin | Homo sapiens |