Title : Copper chaperone Atox1 interacts with the metal-binding domain of Wilson's disease protein in cisplatin detoxification.

Pub. Date : 2013 Aug 15

PMID : 23751120






1 Functional Relationships(s)
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1 Transfer of platinum along the copper-transport pathways in the cell may serve as a mechanism of drug delivery to its target in the cell nucleus, and explain tumour-cell resistance to cisplatin associated with the overexpression of copper transporters ATP7B and ATP7A. Platinum ATPase copper transporting beta Homo sapiens